澳门正规十大网赌官网 - 十大网赌网址信誉排行榜-平台推荐

- 姓名：张爽
- 职务：
- 职称：副教授
- 所属系：药物科学与工程系
- 邮箱：zhangshuang@hfut.edu.cn
- 办公地点：澳门正规十大网赌官网507

个人简介
研究领域
科研项目
学术成果
荣誉奖项

学习经历：

2011年9月-2015年6月，毕业院校：中国海洋大学海洋生命学院，学历：大学本科

2015年9月-2020年6月，毕业院校：南开大学生生命科学学院，学历：博士研究生

工作经历：

2020年12月-至今，澳门正规十大网赌官网，副教授

重大疾病（肝脏疾病、心血管疾病）的药理学和分子机理研究。

1. 十大网赌网址信誉排行榜“黄山学者学术骨干”人才引进科研启动经费。
2. 十大网赌网址信誉排行榜学术新人提升计划A项目，孕期糖脂代谢稳态调控新机制：孕酮诱导ChREBP，项目编号：JZ2021HGTA0127，结题，主持。
3. 横向项目：复方丹参滴丸改善血管钙化的药效及分子机制研究，项目编号：W2023JSFW0071，在研，主持。
4. 横向项目：芪参益气滴丸治疗糖尿病心肌病的体外药效机理研究，项目编号：W2022JSFW0883，结题，主持。

代表性论文：

1. Zhang S（第一作者）, Guo F, Yu M, Yang X, Yao Z, Li Q, Wei Z, Feng K, Zeng P, Zhao D, Li X, Zhu Y, Miao QR, Iwakiri Y, Chen Y*, Han J*, Duan Y*. Reduced Nogo expression inhibits diet-induced metabolic disorders by regulating ChREBP and insulin activity. J Hepatol. 2020 Dec;73(6):1482-1495.

2. Zhang S#（共同第一作者）, Yu M#, Guo F, Yang X, Chen Y, Ma C, Li Q, Wei Z, Li X, Wang H, Hu H, Zhang Y, Kong D, Miao QR, Hu W, Hajjar DP, Zhu Y, Han J*, Duan Y*. Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ12,14-PGJ2 and Nogo. Br J Pharmacol. 2020 Mar;177(5):1041-1060.

3. Yu M#, Zhang S#（共同第一作者）, Guo F, Yang X, Li Q, Wei Z, Han J, Duan Y*, Chen Y*. Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma. Cell Signal. 2020 Jan;65:109429.

4. Yin Z#, Wang X#, Zheng S, Cao P, Chen Y, Yu M, Liao C, Zhang Z, Han J, Duan Y, Yang X*, Zhang S*（通讯作者）. LongShengZhi Capsule Attenuates Alzheimer-Like Pathology in APP/PS1 Double Transgenic Mice by Reducing Neuronal Oxidative Stress and Inflammation. Front Aging Neurosci. 2020 Nov 23;12:582455.

5. Wang X#, Yin Z#, Cao P, Zheng S, Chen Y, Yu M, Liao C, Zhang Z, Duan Y, Han J, Zhang S*（通讯作者）, Yang X*. NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines. Biomed Pharmacother. 2021 Jan;133:110964.

6. Wang X, Yin Z, Meng X, Yang D, Meng H, Liao C, Wei L, Chen Y, Yang X, Han J, Duan Y*, Zhang S*（通讯作者）. Daidzein alleviates neuronal damage and oxidative stress via GSK3β/Nrf2 pathway in mice. Journal of Functional Food. 92 (2022) 105060.

7. Li H#, Zhang M#, Wang Y, Gong K, Yan T, Wang D, Meng X, Yang X, Chen Y, Han J, Duan Y*, Zhang S*（通讯作者）. Daidzein alleviates Doxorubicin-induced heart failure via SIRT3/FOXO3a signaling pathway. Food & Function. 2022 Sep 22;13(18):9576-9588.

8. Chen Y, Yang S, Liu L, Yang X, Duan Y, Zhang S*（通讯作者）, Han J*. A novel therapy for hepatic cholestasis treatment—the combination of rosiglitazone and fenofibrate. European Journal of Pharmacology. 938 (2023) 175428.

9. Zhang F#, Wang M#, Zha Y, Zhou J, Han J*, Zhang S*（通讯作者）. Daucosterol Alleviates Alcohol-Induced Hepatic Injury and Inflammation through P38/NF-kB/NLRP3 Inflammasome Pathway. Nutrients. 2023, 15, 223.
10. Yu M, Jiang M, Chen Y, Zhang S, Zhang W, Yang X, Li X, Li Y, Duan S, Han J, Duan Y. Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low-Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A Peroxisome Proliferator-Activated Receptor (PPAR)g-Dependent Mechanism. J Biol Chem. 2016 Aug 12;291(33):16977-89.

11. Li Q, Chen Y, Zhao D, Wei Z, Zhang S, Chen Y, Wang Y, Qian K, Zhao B, Zhu Y,Gao X, Dong P, Li X, Duan Y, Han J, Yang X. NaoXinTong Capsule Inhibits Carrageenan-Induced Thrombosis in Mice. J Cardiovasc Pharmacol. 2018 Jul;72(1):49-59.

12. Li Q, Chen Y, Zhao D, Yang S, Zhang S, Wei Z, Wang Y, Qian K, Zhao B, Zhu Y, Chen Y, Duan Y, Han J, Yang X. LongShengZhi Capsule reduces carrageenan-induced thrombosis by reducing activation of platelets and endothelial cells. Pharmacol Res. 2019 Jun;144:167-180.

13. Ma J, Zhao D, Wang X, Ma C, Feng K, Zhang S, Chen Y, Zhu Y, Gao X, Zhao B, Wang Y, Qian K, Li X, Duan Y, Han J, Yang X. LongShengZhi Capsule Reduces Established Atherosclerotic Lesions in apoE-Deficient Mice by Ameliorating Hepatic Lipid Metabolism and Inhibiting Inflammation. J Cardiovasc Pharmacol. 2019 Feb;73(2):105-117.

14. Wei Z, Zhao D, Zhang Y, Chen Y, Zhang S, Li Q, Zeng P, Li X, Zhang W, Duan Y, Han J, Yang X. Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-κB-TNF-α signaling pathway in a PPARγ-dependent manner. Biochem Biophys Res Commun. 2019 Nov 19;519(4):854-860.

15. Zhao D, Xue C, Li J, Feng K, Zeng P, Chen Y, Duan Y, Zhang S, Li X, Han J, Yang X. Adiponectin agonist ADP355 ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and oxidative stress. Biochem Biophys Res Commun. 2020 Dec 10;533(3):304-312.

16. Feng K, Ma C, Liu Y, Yang X, Yang Z, Chen Y, Xu T, Yang C, Zhang S, Li Q, Wei Z, Zhao D, Zeng P, Han J, Gao J, Chen Y, Duan Y. Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR- induced lipogenesis. Theranostics. 2021 Jan 1;11(6):2634-2654.

17. Chen Y, Hu W, Li Q, Zhao S, Zhao D, Zhang S, Wei Z, Yang X, Chen Y, Li X, Liao C, Han J, Miao QR, Duan Y. NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Jan-Jun;296:100624.

18. Zheng S, Cao P, Yin Z, Wang X, Chen Y, Yu M, Xu B, Liao C, Duan Y, Zhang S, Han J, Yang X. Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis. Food Funct. 2021 Mar 15;12(5):2323-2334.

19. Liang Y, Chen G, Zhang F, Yang X, Chen Y, Duan Y, Yu M, Zhang S, Han J. Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway. Antioxidants (Basel). 2021 Jun 5;10(6):916.

20. Zhang B, Huang R, Yang D, Chen G, Chen Y, Han J, Zhang S, Ma L, Yang X. Combination of Colchicine and Ticagrelor Inhibits Carrageenan-Induced Thrombi in Mice. Oxid Med Cell Longev. 2022 Jan 17;2022:3087198.

21. Wang X, Yang Y, Zhao D, Zhang S, Chen Y, Chen Y, Feng K, Li X, Han J, Iwakiri Y, Duan Y, Yang X. Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms. J Biol Chem. 2022 Feb;298(2):101561.

22. Yan Y, Zhu M, Ma J, He X, Yang X, Xu H, Jiang M, Zhang S, Duan Y, Han J, Chen Y. MEK1/2 inhibitor inhibits neointima formation by activating miR-126-3p/ C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) axis. Bioengineered. 2022 Apr;13(4):11214-11227.

专利：
1.治疗葡萄糖和或脂质代谢紊乱的药物和治疗葡萄糖和或脂质代谢紊乱的方法（美国专利），专利授权号：132257-00102.

2.Nogo-B抑制剂在制备治疗糖脂代谢紊乱药物中的应用和治疗糖脂代谢紊乱的药物，公开。

3.虾青素联用阳性药在制备用于改善胆汁淤积性肝病的药物中的应用，公开。

1.2018年中华医学科学技术奖三等奖“动脉粥样硬化干预靶点与机制研究”。
2.2018年第十四届全国脂质与脂蛋白学术会议青年优秀论文大赛奖。
3.2018年美国Experimental Biology 2018学术会议 ASBMB Travel Award。
4.2019年动脉粥样硬化干预靶点与机制研究中华医学会科技奖三等奖。
5.2019年南开大学博士研究生国家奖学金、博士研究生一等奖学金。
6.2020年安徽省细胞生物学会口头报告一等奖。
7.2022年安徽省病理生理学心血管疾病专业委员会优秀墙报特等奖。

职务：		职称：	副教授
所属系：	药物科学与工程系	邮箱：	zhangshuang@hfut.edu.cn
办公地点：	澳门正规十大网赌官网507	学术成果	<br>代表性论文：<br> <br>1. Zhang S（第一作者）, Guo F, Yu M, Yang X, Yao Z, Li Q, Wei Z, Feng K, Zeng P, Zhao D, Li X, Zhu Y, Miao QR, Iwakiri Y, Chen Y, Han J, Duan Y. Reduced Nogo expression inhibits diet-induced metabolic disorders by regulating ChREBP and insulin activity. J Hepatol. 2020 Dec;73(6):1482-1495.<br> <br>2. Zhang S#（共同第一作者）, Yu M#, Guo F, Yang X, Chen Y, Ma C, Li Q, Wei Z, Li X, Wang H, Hu H, Zhang Y, Kong D, Miao QR, Hu W, Hajjar DP, Zhu Y, Han J, Duan Y. Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ12,14-PGJ2 and Nogo. Br J Pharmacol. 2020 Mar;177(5):1041-1060.<br> <br>3. Yu M#, Zhang S#（共同第一作者）, Guo F, Yang X, Li Q, Wei Z, Han J, Duan Y, Chen Y. Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma. Cell Signal. 2020 Jan;65:109429.<br> <br>4. Yin Z#, Wang X#, Zheng S, Cao P, Chen Y, Yu M, Liao C, Zhang Z, Han J, Duan Y, Yang X, Zhang S（通讯作者）. LongShengZhi Capsule Attenuates Alzheimer-Like Pathology in APP/PS1 Double Transgenic Mice by Reducing Neuronal Oxidative Stress and Inflammation. Front Aging Neurosci. 2020 Nov 23;12:582455.<br> <br>5. Wang X#, Yin Z#, Cao P, Zheng S, Chen Y, Yu M, Liao C, Zhang Z, Duan Y, Han J, Zhang S（通讯作者）, Yang X. NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines. Biomed Pharmacother. 2021 Jan;133:110964.<br> <br>6. Wang X, Yin Z, Meng X, Yang D, Meng H, Liao C, Wei L, Chen Y, Yang X, Han J, Duan Y, Zhang S（通讯作者）. Daidzein alleviates neuronal damage and oxidative stress via GSK3β/Nrf2 pathway in mice. Journal of Functional Food. 92 (2022) 105060.<br> <br>7. Li H#, Zhang M#, Wang Y, Gong K, Yan T, Wang D, Meng X, Yang X, Chen Y, Han J, Duan Y, Zhang S（通讯作者）. Daidzein alleviates Doxorubicin-induced heart failure via SIRT3/FOXO3a signaling pathway. Food & Function. 2022 Sep 22;13(18):9576-9588.<br> <br>8. Chen Y, Yang S, Liu L, Yang X, Duan Y, Zhang S（通讯作者）, Han J. A novel therapy for hepatic cholestasis treatment—the combination of rosiglitazone and fenofibrate. European Journal of Pharmacology. 938 (2023) 175428.<br> <br>9. Zhang F#, Wang M#, Zha Y, Zhou J, Han J, Zhang S*（通讯作者）. Daucosterol Alleviates Alcohol-Induced Hepatic Injury and Inflammation through P38/NF-kB/NLRP3 Inflammasome Pathway. Nutrients. 2023, 15, 223. <br>10. Yu M, Jiang M, Chen Y, Zhang S, Zhang W, Yang X, Li X, Li Y, Duan S, Han J, Duan Y. Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low-Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A Peroxisome Proliferator-Activated Receptor (PPAR)g-Dependent Mechanism. J Biol Chem. 2016 Aug 12;291(33):16977-89.<br> <br>11. Li Q, Chen Y, Zhao D, Wei Z, Zhang S, Chen Y, Wang Y, Qian K, Zhao B, Zhu Y,Gao X, Dong P, Li X, Duan Y, Han J, Yang X. NaoXinTong Capsule Inhibits Carrageenan-Induced Thrombosis in Mice. J Cardiovasc Pharmacol. 2018 Jul;72(1):49-59.<br> <br>12. Li Q, Chen Y, Zhao D, Yang S, Zhang S, Wei Z, Wang Y, Qian K, Zhao B, Zhu Y, Chen Y, Duan Y, Han J, Yang X. LongShengZhi Capsule reduces carrageenan-induced thrombosis by reducing activation of platelets and endothelial cells. Pharmacol Res. 2019 Jun;144:167-180.<br> <br>13. Ma J, Zhao D, Wang X, Ma C, Feng K, Zhang S, Chen Y, Zhu Y, Gao X, Zhao B, Wang Y, Qian K, Li X, Duan Y, Han J, Yang X. LongShengZhi Capsule Reduces Established Atherosclerotic Lesions in apoE-Deficient Mice by Ameliorating Hepatic Lipid Metabolism and Inhibiting Inflammation. J Cardiovasc Pharmacol. 2019 Feb;73(2):105-117.<br> <br>14. Wei Z, Zhao D, Zhang Y, Chen Y, Zhang S, Li Q, Zeng P, Li X, Zhang W, Duan Y, Han J, Yang X. Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-κB-TNF-α signaling pathway in a PPARγ-dependent manner. Biochem Biophys Res Commun. 2019 Nov 19;519(4):854-860.<br> <br>15. Zhao D, Xue C, Li J, Feng K, Zeng P, Chen Y, Duan Y, Zhang S, Li X, Han J, Yang X. Adiponectin agonist ADP355 ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and oxidative stress. Biochem Biophys Res Commun. 2020 Dec 10;533(3):304-312.<br> <br>16. Feng K, Ma C, Liu Y, Yang X, Yang Z, Chen Y, Xu T, Yang C, Zhang S, Li Q, Wei Z, Zhao D, Zeng P, Han J, Gao J, Chen Y, Duan Y. Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR- induced lipogenesis. Theranostics. 2021 Jan 1;11(6):2634-2654.<br> <br>17. Chen Y, Hu W, Li Q, Zhao S, Zhao D, Zhang S, Wei Z, Yang X, Chen Y, Li X, Liao C, Han J, Miao QR, Duan Y. NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Jan-Jun;296:100624.<br> <br>18. Zheng S, Cao P, Yin Z, Wang X, Chen Y, Yu M, Xu B, Liao C, Duan Y, Zhang S, Han J, Yang X. Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis. Food Funct. 2021 Mar 15;12(5):2323-2334.<br> <br>19. Liang Y, Chen G, Zhang F, Yang X, Chen Y, Duan Y, Yu M, Zhang S, Han J. Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway. Antioxidants (Basel). 2021 Jun 5;10(6):916.<br> <br>20. Zhang B, Huang R, Yang D, Chen G, Chen Y, Han J, Zhang S, Ma L, Yang X. Combination of Colchicine and Ticagrelor Inhibits Carrageenan-Induced Thrombi in Mice. Oxid Med Cell Longev. 2022 Jan 17;2022:3087198.<br> <br>21. Wang X, Yang Y, Zhao D, Zhang S, Chen Y, Chen Y, Feng K, Li X, Han J, Iwakiri Y, Duan Y, Yang X. Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms. J Biol Chem. 2022 Feb;298(2):101561.<br> <br>22. Yan Y, Zhu M, Ma J, He X, Yang X, Xu H, Jiang M, Zhang S, Duan Y, Han J, Chen Y. MEK1/2 inhibitor inhibits neointima formation by activating miR-126-3p/ C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) axis. Bioengineered. 2022 Apr;13(4):11214-11227.<br> <br>专利： <br>1.治疗葡萄糖和或脂质代谢紊乱的药物和治疗葡萄糖和或脂质代谢紊乱的方法（美国专利），专利授权号：132257-00102.<br> <br>2.Nogo-B抑制剂在制备治疗糖脂代谢紊乱药物中的应用和治疗糖脂代谢紊乱的药物，公开。<br> <br>3.虾青素联用阳性药在制备用于改善胆汁淤积性肝病的药物中的应用，公开。<br>
研究领域	<br>重大疾病（肝脏疾病、心血管疾病）的药理学和分子机理研究。	科研项目	<br>1. 十大网赌网址信誉排行榜“黄山学者学术骨干”人才引进科研启动经费。 <br>2. 十大网赌网址信誉排行榜学术新人提升计划A项目，孕期糖脂代谢稳态调控新机制：孕酮诱导ChREBP，项目编号：JZ2021HGTA0127，结题，主持。 <br>3. 横向项目：复方丹参滴丸改善血管钙化的药效及分子机制研究，项目编号：W2023JSFW0071，在研，主持。 <br>4. 横向项目：芪参益气滴丸治疗糖尿病心肌病的体外药效机理研究，项目编号：W2022JSFW0883，结题，主持。
荣誉奖项	<br>1.2018年中华医学科学技术奖三等奖“动脉粥样硬化干预靶点与机制研究”。 <br>2.2018年第十四届全国脂质与脂蛋白学术会议青年优秀论文大赛奖。 <br>3.2018年美国Experimental Biology 2018学术会议 ASBMB Travel Award。 <br>4.2019年动脉粥样硬化干预靶点与机制研究中华医学会科技奖三等奖。 <br>5.2019年南开大学博士研究生国家奖学金、博士研究生一等奖学金。 <br>6.2020年安徽省细胞生物学会口头报告一等奖。 <br>7.2022年安徽省病理生理学心血管疾病专业委员会优秀墙报特等奖。

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